Detalhe da pesquisa
1.
Refining the impact of genetic evidence on clinical success.
Nature
; 2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38632401
2.
Exome sequencing and characterization of 49,960 individuals in the UK Biobank.
Nature
; 586(7831): 749-756, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33087929
3.
The genetics of drug efficacy: opportunities and challenges.
Nat Rev Genet
; 17(4): 197-206, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26972588
4.
Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort.
J Allergy Clin Immunol
; 147(5): 1830-1837.e15, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33058932
5.
A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.
Gastroenterology
; 156(6): 1707-1716.e2, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30664875
6.
Predicting clinically promising therapeutic hypotheses using tensor factorization.
BMC Bioinformatics
; 20(1): 69, 2019 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30736745
7.
Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.
Gastroenterology
; 152(5): 1078-1089, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28043905
8.
STOPGAP: a database for systematic target opportunity assessment by genetic association predictions.
Bioinformatics
; 33(17): 2784-2786, 2017 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28472345
9.
GWASdb v2: an update database for human genetic variants identified by genome-wide association studies.
Nucleic Acids Res
; 44(D1): D869-76, 2016 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26615194
10.
Characterization of ADME gene variation in 21 populations by exome sequencing.
Pharmacogenet Genomics
; 27(3): 89-100, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27984508
11.
Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population.
J Antimicrob Chemother
; 72(4): 1152-1162, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28062682
12.
HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury.
Pharmacogenet Genomics
; 26(5): 218-24, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26959717
13.
The benefits of using genetic information to design prevention trials.
Am J Hum Genet
; 92(4): 547-57, 2013 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23541341
14.
The influence of genomic context on mutation patterns in the human genome inferred from rare variants.
Genome Res
; 23(12): 1974-84, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23990608
15.
Comparing variant calling algorithms for target-exon sequencing in a large sample.
BMC Bioinformatics
; 16: 75, 2015 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25884587
16.
Multi-population classical HLA type imputation.
PLoS Comput Biol
; 9(2): e1002877, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23459081
17.
Genes mirror geography within Europe.
Nature
; 456(7218): 98-101, 2008 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-18758442
18.
Genome-wide patterns of population structure and admixture in West Africans and African Americans.
Proc Natl Acad Sci U S A
; 107(2): 786-91, 2010 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20080753
19.
Future prospects for human genetics and genomics in drug discovery.
Curr Opin Struct Biol
; 80: 102568, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36963162
20.
Using human genetics to improve safety assessment of therapeutics.
Nat Rev Drug Discov
; 22(2): 145-162, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36261593